Probenceid chemistry name. Probenecid belongs to a class of drugs known as uricosurics. Probenecid is used to treat chronic gout and gouty arthritis. Using probenecid with any of the following medicines is usually not recommended, but may be required in some cases. These side effects may go away during treatment as your body adjusts to the medicine. 43 Probenecid is extensively protein bound, ranging from 83% to 95% depending on the dose. Call your doctor for medical advice about side effects. If you have any questions about this, check with your health care professional. These medications are not usually taken together. Probenecid is sometimes used with certain kinds of antibiotics to make them more effective in the treatment of infections. It is also used to treat or prevent high uric acid levels that occur as a result of certain types of chemotherapy. Your doctor may prescribe an additional medicine called colchicine. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Taking aspirin or other salicylates may lessen the effects of probenecid. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. If you need surgery, tell your surgeon you currently take probenecid. Probenecid may cause false test results with copper sulfate urine sugar tests (Clinitest®), but not with glucose enzymatic urine sugar tests (Clinistix®). The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Probenecid is also used to increase the blood levels of penicillin-type antibiotics used for the treatment of gonorrhea. Copyright 1996-2021 Cerner Multum, Inc. Probenecid: Belongs to the class of preparations increasing uric acid excretion. Severe Interactions . Gout is very rare in children. Version: 4.03. prednisone, allopurinol, triamcinolone, dexamethasone, betamethasone, Decadron, febuxostat, Uloric, Zyloprim, allopurinol / lesinurad. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Probenecid should not be given to a child younger than 2 years old. prednisone, allopurinol, triamcinolone, dexamethasone, betamethasone, Decadron, febuxostat, Uloric, Zyloprim, allopurinol / lesinurad. Probenecid colchicine (probenecid / colchicine) can be used to stop gout attacks but you shouldn't start it until after the gout attack is over. Medscape - Gout dosing for colchicine/probenecid, frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. The presence of other medical problems may affect the use of probenecid. Store at room temperature away from moisture, heat, and light. The amount of medicine that you take depends on the strength of the medicine. Probenceid chemistry name. To help prevent this, your doctor may want you to drink at least 10 to 12 full glasses (8 ounces each) of fluids each day, or to take another medicine to make your urine less acid. Probenecid will help prevent gout attacks only as long as you continue to take it. Probenecid, also sold under the brand name Probalan, is a medication that increases uric acid excretion in the urine. Generic Name: probenecid (proe BEN a sid)Brand Name: BenemidDosage Forms: oral tablet (500 mg). Avoid using any medicine that may contain aspirin or other salicylates (such as Disalsid, Doan's Extra Strength, Ecotrin, Novasal, Nuprin Backache, Salflex, Salsitab, Tricosal, Trilisate, and others). It depends on the child's weight, as well as on the condition being treated. These conditions are caused by too much uric acid in the blood. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Make sure you tell your doctor if you have any other medical problems, especially: If probenecid upsets your stomach, it may be taken with food. Check with your doctor immediately if any of the following side effects occur: Check with your doctor as soon as possible if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Using probenecid with any of the following medicines is not recommended. Probenecid Drug Class. Follow your doctor's orders or the directions on the label. Also, drinking too much alcohol may increase the amount of uric acid in the blood and lessen the effects of probenecid. Using probenecid with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. Using alcohol or tobacco with certain medicines may also cause interactions to occur. You should not use probenecid if you are allergic to it, or if you have: a gout attack that has already started; or. Do not keep outdated medicine or medicine no longer needed. Drug class: Xanthine Oxidase Inhibitors Allopurinol (Zyloprim) is a moderately priced drug used to treat the symptoms of gout . After you begin to take probenecid, gout attacks may continue to occur for a while. These conditions are caused by too much uric acid in the blood. Probenecid does not cure gout, but after you have been taking it for a few months it will help prevent gout attacks. Probenecid will help prevent gout attacks but it will not relieve an attack that has already started. Data sources include IBM Watson Micromedex (updated 3 Mar 2021), Cerner Multum™ (updated 1 Mar 2021), ASHP (updated 3 Mar 2021) and others. Drug class(es): antigout agents Probenecid systemic is used in the treatment of: Adjunct to Antibiotic Therapy; Gout; Gouty Arthritis; Multi-ingredient medications containing probenecid: ampicillin/probenecid systemic. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. Psychic disturbances w/ penicillin or other β-lactams. Probenecid belongs to a class of drugs known as uricosurics. It lowers high levels of uric acid in your body by helping the kidneys to get rid of uric acid. Probenecid is used in the treatment of chronic gout or gouty arthritis. If you miss a dose of probenecid, take it as soon as possible. Other times, the dose will be 1 tablet four times a day. For probenecid, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to probenecid or any other medicines. In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. Uricosric antigout agent. When you are taking probenecid, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Used in the treatment of gout., After this, the dose will depend on the amount of uric acid in your blood or urine. It is best to drink a full glass of water with each dose and at least another 8 glasses (8 ounces each) a day while taking this drug in order to prevent kidney stones. It is also used to increase the effectiveness of some antibiotics. Older children and teenagers may need the same amount as adults. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Call your doctor if your gout symptoms do not improve, or if they get worse. Disclaimer: This information is independently developed by CIMS based on probenecid from various references and is provided for your reference only. This list is not complete. Click card to see definition . The results of some tests may be affected by probenecid. The chemical name for Probenecid is 4-[(dipropylamino) sulfony1] benzoic acid. Probenecid is well absorbed when given orally and provides drug levels equivalent to the IV form, no longer available in the United States. It is used to prevent attacks related to gout, not treat them once they occur. Most cephalosporins are affected to some degree by concurrent probenecid administration, although ceforanide, ceftazidime, ceftriaxone and latamoxef (moxalactam) have no significant changes in pharmacokinetics. Drug class(es): aminopenicillins. Pregnancy risk category B The medicine works by removing the extra uric acid from the body. Medically reviewed by Drugs.com on Dec 9, 2020. Use the medicine exactly as directed. You may be given other medications to also help prevent kidney stones. Your doctor may also instruct you on how to decrease acidity in your urine (e.g., avoid large amounts of ascorbic acid/vitamin C) to pr… Before you have any medical tests, tell the person in charge that you are taking probenecid. Probenecid is also used to make certain antibiotics more effective by preventing the body from passing them in the urine. Review side effects, dosage, warnings and precautions, and drug interactions prior to taking this medication. Probenecid is also sometimes given together with penicillin antibiotics (including ampicillin, methicillin, oxacillin, cloxacillin, or nafcillin) to make them more effective. It is best to drink a full glass of water with each dose and at least another 8 glasses (8 ounces each) a day while taking this drug in order to prevent kidney stones. We comply with the HONcode standard for trustworthy health information -, Cancer being treated by antineoplastics (cancer medicine) or radiation (x-rays) or, Kidney disease or stones (or history of) or, Stomach ulcer (history of)—The chance of side effects may be increased. However, if you take probenecid regularly as directed by your doctor, the attacks will gradually become less frequent and less painful than before. Does PROBENECID Interact with other Medications? Probenecid does not cure gout, but after you have been taking it for a few months it will help prevent gout attacks. Probenecid is also used to prevent or treat other medical problems that may occur if too much uric acid is present in the body. It has the following structural formula: Probenecid, USP is a white or nearly white, fine, crystalline powder. Call your doctor if you have worsening gout symptoms. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Tap again to see term . Follow all directions on your prescription label and read all medication guides or instruction sheets. In these cases, your doctor may want to change the dose, or other precautions may be necessary. nausea, vomiting, stomach pain or swelling; puffy eyes, swelling in your ankles or feet, weight gain; or. Probenecid is used to treat gout and gouty arthritis. Drink plenty of water to prevent kidney stones while you are taking probenecid. Affected cytochrome P450 isoenzymes and drug transporters: OAT1 and OAT3 Probenecid inhibits the drug transporters OAT1 and OAT3. Therefore, do not take aspirin or other salicylates or drink alcoholic beverages while taking probenecid, unless you have first checked with your doctor. Gravity. Your doctor may also instruct you on how to decreas… For patients taking probenecid for gout or to help remove uric acid from the body: The dose of probenecid will be different for different patients. When you first begin taking probenecid, the amount of uric acid in the kidneys is greatly increased. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. After you have been taking probenecid for several months, they may stop completely. Probenecid is a uricosuric and renal tubular blocking agent and is used in combination … Access … If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. If you notice any other effects, check with your healthcare professional. Probenecid systemic 500 mg (MYLAN 156 500), We comply with the HONcode standard for trustworthy health information -. If a child needs probenecid, however, the dose would have to be determined by the doctor. You may report side effects to FDA at 1-800-FDA-1088. Pharmacologic class: Sulfonamide-derived uricosuric. Other drugs may affect probenecid, including prescription and over-the-counter medicines, vitamins, and herbal products. This will depend on the dose of aspirin or other salicylate that you take, and on how often you take it. Data sources include IBM Watson Micromedex (updated 3 Mar 2021), Cerner Multum™ (updated 1 Mar 2021), ASHP (updated 3 Mar 2021) and others. Children: The dose will have to be determined by the doctor. Action of Probenceid-inhibits tubular reabsorption of urates which increase execration of uric acid. You may report side effects to the FDA at 1-800-FDA-1088. Compare formulary status to other drugs in the same class. To prevent gout, take this medication by mouth, usually twice daily with food or antacids to reduce stomach upset or as directed by your doctor. There is no specific information comparing use of probenecid in the elderly with use in other age groups. Along with its needed effects, a medicine may cause some unwanted effects. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Available for Android and iOS devices. If your dose is different, do not change it unless your doctor tells you to do so. The medicine works by removing the extra uric acid from the body. It acts on the kidneys to help the body eliminate uric acid. Probenecid colchicine (probenecid / colchicine) isn’t a first choice medicine to treat or prevent gout. Ask a doctor or pharmacist if you feel you need to take a mild pain reliever. Sometimes, only one dose of 2 tablets is needed. Probenecid (former brand name Benemid) is a drug prescribed for the treatment of gout and kidney stones. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. sulfonamide derrivitive. The effect of concurrent probenecid administration on the pharmacokinetics of cephalosporin antibiotics varies with the available cephalosporins. If this does not work, an antacid may be taken. It has not been shown to cause different side effects or problems than it does in adults. Not all possible drug interactions are listed here. Available for Android and iOS devices. Beta-lactam antibiotics. Probenecid Drug Class. Match. Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Generic Name : Probenecid Pronunciation : proe ben' e sid Latest prescription information about Probenecid. probenecid reduces the amount of uric acid in your body by causing it to be passed in your urine. When uric acid levels get too high, crystals can form in the joints, causing gout. 43 Peak concentrations are reached in 1 to 5 hours, and the peak action occurs about 2 hours after an oral dose with effects lasting up to 8 hours. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Do not double doses. Probenecid may also be used for purposes not listed in this medication guide. [56579] Probenecid inhibits the tubular secretion of penicillin and usually increases penicillin plasma levels by any route the antibiotic is given. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Even if you take another medicine for gout attacks, continue to take probenecid also. Tell your doctor if you are pregnant or breast-feeding. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. If stomach upset (nausea, vomiting, or loss of appetite) continues, check with your doctor. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. This may cause kidney stones or other kidney problems in some people. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. Probenecid belongs to a group of drugs called renal tubular blocking agents. Probenecid Oral tablet drug summary. If you are on restricted fluid intake, consult your doctor for further instructions. Probenecid is a uricosuric and renal tubular transport blocking agent. a blood cell disorder, such as anemia or low white blood cells. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Written by Cerner Multum. Drug Interactions: When probenecid is used to elevate plasma concentrations of penicillin or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. Tell your doctor about all your other medicines, especially: an NSAID (nonsteroidal anti-inflammatory drug) such as indomethacin, ketoprofen, meclofenamate, or naproxen (Aleve). Find everything you need to know about Probenecid (Benemid), including what it is used for, warnings, reviews, side effects, and interactions. Antagonized uricosuric ... M04AB01 - probenecid ; Belongs to the class of preparations increasing uric acid excretion. probenecid reduces the amount of uric acid in your body by causing it to be passed in your urine. Last updated on Nov 20, 2020. Probenecid is also used to prevent or treat other medical problems that may occur if too much uric acid is present in t… This is a decision you and your doctor will make. Probenecid has been tested in children 2 to 14 years of age for use together with antibiotics. SW Probenecid(probenecid): ... Drug Interactions . colchicine/probenecid systemic. puffiness or swellings of the eyelids or around the eyes, shortness of breath, troubled breathing, tightness in chest, or wheezing, changes in the skin color of the face occurring together with any of the other side effects listed here, or skin rash, hives, or itching occurring together with any of the other side effects listed here, lower back or side pain (especially if severe or sharp), skin rash, hives, or itching (occurring without other signs of an allergic reaction), sores, ulcers, or white spots on lips or in mouth, sore throat and fever with or without chills, swelling of face, fingers, feet, and/or lower legs, flushing or redness of face (occurring without any signs of an allergic reaction). Do not take two doses at one time. 1-888-INFO-FDA (1-888-463-6332) Contact FDA There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Uricosric antigout agent. For non-prescription products, read the label or package ingredients carefully. It lowers high levels of uric acid in your body by helping the kidneys to get rid of uric acid. It lowers high levels of uric acid in your body by helping the kidneys to get rid of uric acid. Keep using these medicines for as long as your doctor has prescribed. Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Drug Review Package. If you are on restricted fluid intake, consult your doctor for further instructions. In addition, probenecid modulates the transport of organic acids and acidic drugs at the proximal and distal renal tubule, thereby increasing the drug serum concentration. Call your doctor for medical advice about side effects. To prevent gout, take this medication by mouth, usually twice daily with food or antacids to reduce stomach upset or as directed by your doctor. The following information includes only the average doses of probenecid. Probenecid is used to treat gout and gouty arthritis. Although not all of these side effects may occur, if they do occur they may need medical attention. Click again to see term . 43 Probenecid will help prevent gout attacks only as long as you continue to take it. Probenecid is available only with your doctor's prescription. Generic Name: probenecid (proe-BEN-e-sid). Therapeutic class: Antigout drug, tubular blocking agent. You should not use this medicine if you have uric acid kidney stones, a gout attack that has already started, or a blood cell disorder. flushing (sudden warmth, redness, or tingly feeling); This is not a complete list of side effects and others may occur. Most people need 2, 3, or 4 tablets a day, but some people may need higher doses. probenecid may affect your body's response to anesthesia. If you have any questions about this, check with your doctor. Brand names: Probenecid and Colchicine, Proben-C Drug class(es): antigout agents Tap card to see definition . Probenecid is soluble in dilute alkali, in alcohol, in chloroform, and in acetone; it is practically insoluble in water and in dilute acids. Probenecid is also sometimes given together with penicillin antibiotics (including ampicillin, methicillin, oxacillin, cloxacillin, or nafcillin) to make them more effective. Find medication information including related drug classes, side effects, patient statistics and answers to frequently asked questions. Select one or more newsletters to continue. Adults: The amount of probenecid will depend on the condition being treated. Probenecid is used in the treatment of chronic gout or gouty arthritis. Keep from freezing. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. Visit cvs.com for more details. Used in the treatment of gout. Children: It is not likely that probenecid will be needed to treat gout or to remove uric acid from the body in children. Each tablet for oral administration contains 500 mg of Probenecid and the following inactive ingredients: Microcrystalline ce… Probenecid has been used in patients with some renal impairment, but dosage requirements may be increased; probenecid may not be effective in chronic renal insufficiency particularly when the glomerular filtration rate is ≤30 mL/minute because of its mechanism of action, probenecid is not recommended in conjunction with penicillin in the presence of known renal impairment Studies on the effects of probenecid in patients with gout have been done only in adults. Medically reviewed by Drugs.com. NCI Thesaurus (NCIt) Probenecid is a uricosuric agent used for the treatment of gout usually in combination with other agents. 10903 New Hampshire Avenue Silver Spring, MD 20993 Ph. Uses of Probenecid-hyperurrcemia in gout-gouty arthritis For treating gout or removing uric acid from the body: Adults: 250 mg (one-half of a 500-mg tablet) two times a day for about one week, then 500 mg (one tablet) two times a day for a few weeks. It is important that you follow your doctor's instructions very carefully. Many medicines have not been studied specifically in older people. Probenecid belongs to a class of drugs known as uricosurics. M04AB01 - probenecid ; Belongs to the class of preparations increasing uric acid excretion. It is primarily used in treating gout and hyperuricemia. Probenecid is a prescription medication used to treat high uric acid levels associated with gout and gouty arthritis. Probenecid Drug Class : Uric acid (Uricosuric) Brand Names : Generic only